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YWIB-Chicago: Young Women In Bio Virtual Book Club, July 29, 2020

Posted By Sharon Sintich, 7 hours ago
On July 29, 2020, a group of middle school girls attended YWIB-Chicago's first virtual book club. College student, Anagha Aneesh, moderated a discussion of the bestselling memoir "Lab Girl" by Hope Jahren. The girls had an opportunity to share their thoughts on the book and to meet WIB members. WIB members shared their own experiences in academia and compared those experiences with those of the author. 

The next virtual book club will take place on October 29, 2020, and will discuss the fictional book: "The Evolution of Calpurnia Tate" by Jacqueline Kelly. 

The goal of the book club is for middle school girls to meet other girls interested in STEM, learn about different aspects of science, and have an opportunity to talk to high school girls and Women In Bio members about their educational paths and STEM careers. The book club will be ongoing and will meet using Zoom about every four to eight weeks.

Tags:  2020  Chicago 

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YWIB-National: Being Brave, Not Perfect - a Webinar With Young Women In Bio and Girls Who Code, August 19, 2020

Posted By Stephanie Allen , Monday, August 31, 2020

We are excited about our partnership with Girls Who Code and thrilled with the success of our first partnership event. We were so inspired by all of our panelists and hope you were too. The closing remarks of each were words that we can continue to reflect on as we navigate our futures.

Anna Greka, MD, Ph.D., Institute Member and Director of Kidney Disease Initiative at Broad Institute, never forgets her superhero, Marie Curie, a remarkable scientist, who always had the courage to continue and is the only human being with two Nobel prizes in separate fields. She earned a Nobel prize in physics and chemistry!

Melanie Dirks, Ph.D., professor of Psychology at McGill University, encourages young women to find mentors, especially if you are not currently surrounded by role models. Melanie suggests you look to organizations like Girls Who Code and Young Women In Bio to connect with new peers and new mentors. Absolutely! Helping young women connect with peers and find new mentors is central to the YWIB mission. YWIB has a number of programs that we encourage you to check out. Some examples of our programs include peer and mentor connection with YWIB Ambassador and educational opportunities such as YWIB Online.

Rebecca Velez Frey, PharmD, Commercial Operating Officer, at EvolveImmune Therapeutics, encourages young women as they move into their careers to get comfortable with the words, "I don't know", continue to have a learning mindset, and don't be afraid to step into the unknown. Rebecca's words of wisdom are that you may not be able to know where your career will go at the beginning, don't hold back on your aspirations, it will be fulfilling and rewarding.

Check out the recording of this webinar here

Tags:  2020  National 

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WIB-Southern California: Young Women In Bio – Discovering Drug Development at Ferring Pharmaceuticals, July 28, 2020

Posted By Kristina Herbert, Wednesday, August 5, 2020

Young Women In Bio-Southern California (YWIB-Southern California) was delighted to partner with Ferring Pharmaceuticals in San Diego to host  “Discovering Drug Development!” This program was specifically for the summer interns from Scripps Research Institute, who are uniquely taking part in virtual internships from the comfort of their homes all across the country.


20 students logged into Zoom, where they were greeted by the Chair of YWIB-Southern California, Kristina Herbert, Ph. D., who provided a brief introduction to YWIB. She said, “YWIB gives girls today the inspiration and support they need to become tomorrow’s leaders in science, technology, engineering, and math (STEM).” She emphasized that YWIB strives to provide education and hands-on experiences in STEM and share our passion for all scientific fields, making these activities and workshops available to all students, regardless of gender. However, the mission is to bridge the gender gap in STEM by highlighting successful female scientists that can serve as role models for young women hoping to pursue STEM. She expressed enthusiasm that the new virtual format for events would allow YWIB to reach even more students in the future, potentially not located near one of YWIB’s 13 chapters in North America. Dr. Herbert encouraged participants to attend virtual events hosted by any of these chapters and to explore the various events already available for viewing on the YWIB YouTube channel.


Dr. Jolene Lau, Ph.D., a senior research analyst at Ferring, then welcomed the Scripps interns virtually to the San Diego Ferring site. She shared with students that her own path to Ferring had also involved time at Scripps Research Institute. She researched recombinant viral nanoparticles to earn her Ph. D. in Chemistry. Dr. Lau then provided a quick, but thorough, overview of Ferring the company, the business of drug research and development, the breadth of molecules that are used as drugs, and how these are optimized.


Founded in 1950, Ferring is a privately owned, research-driven specialty biopharmaceutical group headquartered in Switzerland. With a global presence in over 110 countries worldwide, the San Diego based Ferring group is one of 13 research and development centres worldwide, and they specialize in developing drugs for reproductive medicine and maternal health, gastroenterology, and urology. While the San Diego site specializes in preclinical development, Dr. Lau provided an overview of the path a drug must traverse to market. She underscored the types of data that are collected within each phase of a clinical trial, the percentage of drugs that advance through each phase, the number of patients involved in each clinical trial, and the average cost per patient of these trials. The total to bring a drug to market was ~$1.4 billion. Even then she showed that many drugs may not succeed on the market for the following reasons:

  1. Poor timing, perhaps a drug that performs equally well, was available earlier.
  2. The drug does not perform better than previous drugs, one only finds out how well the drug performs compared to the current standard of care in phase III trials after significant investment.
  3. Low patient or doctor interest, the drug must provide a significant advantage over the current standard of care.
  4. Poor business decisions, i.e. pricing blunders or poor marketing strategies.

Because of the significant investment in developing a drug, if it makes it successfully to market, the innovating drug developer is provided a certain level of patent and regulatory protection before generic manufacturers can launch their own products. Given the focus on research and development at the San Diego site, Dr. Lau highlighted that the reinvestment into research and development is a necessity across not just the pharmaceutical industry, but all innovation and technology-driven fields.


Dr. Lau then expressed her regret that the students were not able to break off into groups to tour the laboratories at Ferring but showed some photos of scientists in the labs. She provided a brief description of the cyclic preclinical drug development process pursued at the San Diego site. First, chemists will work to design and synthesize molecules that might become drugs. These molecules will be tested within in vitro biological assays to find the molecules that give the desired result. Those that function in in vitro assays are then optimized for their pharmacokinetic properties, or how they break down in the body, before testing within in vivo animal models to determine whether the drugs improve the symptoms of disease. Molecules may return to the chemists to be redesigned and optimized at any of these multiple steps.


After this incredible summary of the drug development process, the program transitioned to a career panel, moderated by Dr. Herbert. In addition to Dr. Lau, the panel was composed of two additional accomplished women working in different capacities at the San Diego Ferring site. Students were first introduced to Erica Schoeller, Ph.D., a research scientist who works to identify new drug targets in the reproductive medicine and maternal health therapeutic area. As the one panelist that works at the bench, she spoke to the difficulties in conducting lab work in this time of COVID-19. While she does go into the lab, her time there is limited and focused on getting tasks done. She expressed that she misses the ability to interact and discuss science with colleagues casually.

 

On the other hand, Mimika Koletsou, MS, MBA, a senior informatics analyst, currently the business lead for a drug discovery data project and a core member of the global R&D data strategy team, described how the current pandemic has broken down some barriers. With virtual meetings and working from home now the norm, the colleagues she works with from many of Ferring’s sites around the world no longer seem so distant. There is a new sense that everybody is in the same boat; working with remote colleagues is no different than working with somebody on the other side of the country or ocean. Dr. Lau, who students had already heard from, then looked into her day-to-day as a senior analyst. She described that her position entails providing scientific and competitive intelligence to drug discovery teams at Ferring. Thus, she does a lot of reading and computer searches like a detective to uncover articles and information to support her colleagues across multiple therapeutic areas. This work requires her to, rather than be very focused, have extremely broad expertise across the many areas that Ferring works.


There were several important takeaways from the panel discussion. First, the recent advances in technology and regulations requiring data sharing have led to a wealth of available and easily accessible data. Additionally, new experimental techniques and easy access to kits and cell lines mean that research can progress faster. Thus, the volume of papers published has expanded, and we now have easy access to all of these publications. The deluge of information and data available to researchers necessitates that students be versed in data analysis skills that allow them to take advantage of these datasets and/or develop skills to sift through information quickly to avoid data overload. Besides these technical skills, the panelists all agreed that learning to communicate confidently and clearly and is willing to listen with an open mind to people with differing views is essential. Drug development is a team process, and even science in academia is increasingly done in large collaborative teams. Thus, learning to work in groups is essential for a successful career in STEM.


Students were then given an opportunity to hone their teamwork skills by participating in an exercise on drug naming and pitch presentations. Dr. Lau introduced students to the fact that drugs usually have two names, the brand name, and the generic name. The brand name, which is specific to the drug manufacturer, is approved by the FDA, cannot suggest effectiveness, and should not be easily confused with other drug names. Groups were then given eight drug names and indications that they were supposed to pair, without resorting to online searches. Putting themselves in the shoes of a marketing executive and a member of the medical affairs team, they then had to choose one drug with its indication for which to create a marketing tagline and list of benefits to patients, respectively. Teams seemed to use a combination of familiarity with the drugs and simple word association to pair drugs. One team, remarkably, got all eight pairs correct, while another team used stock images found online to convince their peers that their drug was one they wanted to ask their doctor about. The event ended with a Zoom poll to determine the winning marketing tagline and medical affairs groups.


The event was a great success, and everyone expressed their hopes that it can be repeated in the future at Ferring!

Tags:  2020  Southern California 

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WIB-Metro New York: Young Women In Bio - Life Sciences Entrepreneurship with Alexandria LaunchLabs, July 23, 2020

Posted By Wendy Diller , Tuesday, July 28, 2020

Young Women In Bio-Metro New York and Alexandria LaunchLabs held an informative, energizing mid-summer ZOOM meeting on July 23, 2020, with ~40 high school young women on life sciences entrepreneurship. Hats off to organizer Agata Magalinskaya, a director at Alexandria and vice-chair of YWIB-Metro New York for brilliant moderating. Thanks, also to our presenters (all Ph.D.s turned entrepreneurs), for sharing their stories: Chandrabali Ghose-Paul of Bioharmony Therapeutics; Chiara Vardabasso and Trinna Cuellar of Gotham Therapeutics; Sigi Benjamin-Hong and Yukie Takabatake of Yesse Technologies; Dori Karyat of Synthis, and Whitney Snider, head of Alexandria LaunchLabs NYC.


Tags:  2020  New York 

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YWIB-RTP: What Happens in Clinical Trials & Why Technology Is Needed to Help Speed up the Process!, May 14, 2020

Posted By Kaitlyn Bacon, Monday, July 27, 2020

On May 14, 2020, Young Women In Bio-RTP hosted a virtual webinar in collaboration with Datacubed Health for middle and high school girls to learn about clinical trials. Around 35 girls attended this virtual event! The webinar was led by two Datacubed employees, Jennifer Cho (Deputy Chief Scientific Officer) and Pooja Rajguru (Lead Project Manager). Jennifer began the webinar with a discussion on the steps companies take to get drugs to market, ranging from initial discovery research to clinical trials. She emphasized the four different phases of clinical trials describing which patients receive the drugs in particular phases as well as the scientific goal of each phase. After, she talked about the different roles that sponsors, site staff, and patients have when conducting clinical trials of new drugs. Jennifer ended by discussing the role that technology plays in clinical trials. In particular, advances in technology are helping to save time and money, expand data collection, and increase the diversity of patients participating in studies. In particular, technology, like mobile apps, is allowing scientists and doctors to collect patients’ data more efficiently and in real-time. The knowledge gained from real-time data collection will help speed up and improve the drug development process.


Next, Pooja did a live demonstration of Datacubed Health’s technology that is helping to revolutionize how patient data is collected. They are using behavioral science to make clinical trial participation easier and fun for patients. Datacubed has developed a mobile app that can be used to collect data from patients in real-time and from the convenience of patient’s homes. When patients submit data in the app, they receive rewards that encourage their participation. Some data is even collected through games that patients play within the app. Datacubed Health is also incorporating geofencing and telemedicine into their technology to better help patients connect with medical professionals.

Young Women In Bio-RTP would like to thank our speakers, Jennifer and Pooja, for a very informative talk as well as answering the student’s questions! We appreciate Datacubed Health for sharing their technology. By being able to see the mobile app in action, the girls were able to grasp just how important technology will be in revolutionizing medicine.

Tags:  2020  RTP 

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YWIB-RTP: COVID-19 Question and Answer with Local Virus Experts for Middle & High School Students, June 23, 2020

Posted By Kaitlyn Bacon, Thursday, July 9, 2020
On June 23, 2020, Young Women In Bio-RTP hosted a second virtual webinar for middle and high school girls to learn about the COVID-19 pandemic. Previously, we hosted a webinar on COVID-19 in April 2020. Dr. Stephanie Langel and Dr. Julie Steinbrink, from the Duke University Health System, once again led the discussion. Over 30 girls from the RTP area and throughout the U.S. attended the webinar

The webinar began with an overview of the origins of COVID-19 and what causes this disease. After, the speakers talked about the symptoms of COVID-19 with a focus on emerging symptoms like Pediatric Multisystem Inflammatory Syndrome. A big question in the media is if the virus is mutating. Dr. Langel spent a great time explaining how the virus is mutating and what this could mean in terms of vaccine development. Also highlighted was the difference between PCR based testing and antibody-based testing to determine if a person has been exposed to the SARS-CoV-2 virus. Dr.Steinbrink additionally spent time going over possible treatments for COVID-19 and the science behind these treatments. She explained why certain treatments, like hydroxychloroquine, may not actually help fight COVID-19. Lastly, the webinar concluded with a discussion on the racial and ethnic disparities of COVID-19. At the end of the webinar, the student participants had the chance to ask questions. The girls were curious about if it was safe for them to go back to school and if the world will ever return to normal. They also asked about how the virus moved from animals to humans. Additionally, the girls pondered how antibody treatments and vaccines are developed. 

We would like to thank our two speakers, Dr. Stephanie Langel and Dr. Julie Steinbrink. We appreciate their ability to break down the science surrounding COVID-19 for a general audience. Their discussion was very easy to grasp. We also appreciate their enthusiasm for answering all of the girls' questions. 

A recorded version of the webinar can be found here

Tags:  2020  RTP 

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YWIB-RTP: Operation Outbreak! A Virtual Webinar on Virus Biology for High School Students, April 28, 2020

Posted By Kaitlyn Bacon, Thursday, July 9, 2020

On April 28, 2020, Young Women In Bio-RTP hosted a virtual event entitled, “YWIB-RTP: Operation Outbreak! A Virtual Webinar on Virus Biology for High School Students.” The webinar featured two speakers from the Duke University Health System, Dr. Stephanie Langel, and Dr. Julie Steinbrink. Drs. Langel and Steinbrink provided information on the coronavirus SARS-CoV-2 biology and the disease that it causes, COVID-19.

Our first speaker, Dr. Langel graduated with her Ph.D. in Immunology and Virology from the Ohio State University and is currently a postdoctoral research fellow at the Duke Human Vaccine Institute. Dr. Langel shared her knowledge regarding coronavirus biology that she has gained through her years of research during graduate school and her postdoctoral training. Topics covered by Dr. Langel include: what makes the coronavirus infectious, how does the virus get into cells, what happens when SARS-CoV-2 enters your body and the origin of the virus. 

Our second speaker, Dr. Julie Steinbrink graduated with her medical degree from the University of Pittsburgh and completed her residency training in Internal Medicine at the University of Michigan. She is currently a Chief Infectious Diseases Fellow at the Duke University Medical Center. Dr. Steinbrink shared her clinical expertise on the disease COVID-19. Topics covered by Dr. Steinbrink include the symptoms, which populations are at risk, and treatment options for COVID-19. Dr. Steinbrink also discussed the importance of social distancing, washing your hands, and masks in protecting yourself and preventing the spread of the disease. 

Following our featured speakers, Dr. Stephanie Ham, a YWIB volunteer and Science Director at Metabolon provided a summary of the COVID-19 research and clinical studies that are currently being performed by companies in the Research Triangle Park area. 

The webinar was a success, approximately 65 high schoolers logged into the webinar! During the webinar, the attendees were able to write questions to be answered by our speakers. The speakers received so many great questions from the inquisitive audience that the seminar was extended an extra 30 mins to answer all the submitted questions. 

We would like to thank our guest speakers Dr. Langel and Dr. Steinbrink. They did an amazing job answering questions and relaying information in a way that was easily understood. We would also like to thank Carrie Palsson from the National Women In Bio organization for providing training and tips to ensure the webinar ran as smoothly as possible. 

A recorded version of the webinar can be found here.


Tags:  2020  RTP 

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YWIB-Southern California: Genomes, Germs, and Jewelry – Part 1: DNA on Display!, July 1, 2020

Posted By Kristina M Herbert, Wednesday, July 8, 2020
 Young Women In Bio-Southern California’s (YWIB-Southern California's) first of three virtual experiential summer learning events for middle and high school students, entitled “DNA on Display!”, took place last week on Zoom. The event was designed to encourage young women and girls to pursue STEM (Science, Technology, Engineering, Math) interests and become tomorrow’s leaders that will help to bridge the gender gap and foster diversity in STEM. Over 34 students from more than 20 schools in Southern California and additional locations across the country participated in this event to bring science-themed jewelry to students. Sponsored by Scientist.com and New England Bio Labs, YWIB-Southern California was able to send jewelry and science supplies to registered students so that they would be able to engage in hands-on learning, even in this remote setting. The event featured Julia Picker, Kaitlyn Wang, Lily Pfeizer, April Zou, and Kaley Mafong from Biopolis, a student-run organization at Canyon Crest Academy that engages San Diego youth in exciting experiments in order to ignite an early love of science, as well as Kjerstie Bourne a sale representative at Elim Bio a Contract Research Organization (CRO) that provides a variety of DNA sequencing and purification services.

Dr. Kristina Herbert – the Chair of YWIB-Southern California initiated the event with a brief introduction to YWIB – telling the audience that “YWIB gives girls today the inspiration and support they need to become tomorrow’s leaders in science, technology, engineering, and math (STEM).” She expressed enthusiasm that the new virtual format for events would allow YWIB to reach even more students in the future, potentially students not located near one of YWIB’s 13 chapters in North America. Dr. Herbert encouraged participants to attend events at any one of these chapters and gave brief introductions to both the National YWIB Ambassador initiative, launched this past Spring, and the YWIB-Southern California Biotech Influencers program, which will start in the Fall.

Then Julia and Kaitlyn gave a short introduction to themselves and Biopolis, the science outreach organization the two co-founded. Julia explained that Biopolis was initiated and is still run off of funds the organization earned from a summer 2019 biotech camp they hosted for younger students in their community of Carmel Valley. These funds have allowed them to engage underserved youth in hands-on STEM activities. Biopolis has partnered with Solutions for Change, an organization that provides services to help families escape homelessness, organizing STEM-themed activities for the children, while parents attend meetings or educational services. Kaitlyn also described their partnership with the Children’s Initiative to bring after school STEM activities targeting 4th through 6th graders. Studies have found that if students within this age range develop an interest in STEM during these years, they are much more likely to pursue it later in life. The girls also advertised their new virtual camp for this summer (https://www.projectbiopolis.org/virtual-science-enrichment-classes), the proceeds of which will allow them to continue to do STEM outreach in the Fall.

The young women of Biopolis were truly inspirational, with each girl Julia, Kaitlyn, Lily, April, and Kaley, describing what excites them about science. Whether it’s the ability to discover something new that nobody has observed before, understanding the world better, being able to help society with the discovery of a drug or vaccine, or getting to work with others towards a common goal, they are all passionate about the work they do in Biopolis. Lily expanded on how working with Biopolis allowed her to discover that communicating and teaching science brings her happiness. Then, Julia and Kaitlyn encouraged students to pursue internships in research labs for the summer, emphasizing the number of e-mails that one might need to send before finally getting a positive response, and Lilly described ways to get involved in STEM within schools.

Next, the young women of Biopolis described the science of DNA extraction and what each of the steps are designed to accomplish. The dish soap dissolves the fatty cell membranes in order to release the cellular contents, including DNA. Pineapple juice, contact lens solution, or meat tenderizer is added to further degrade the other contents of the cells. Salt is added to neutralize the negatively charged DNA backbone allowing DNA to fold on itself and then isopropyl alcohol is added to finally precipitate the DNA. Julia demonstrated the extraction from her own saliva and then showed students how to add the their very own DNA to the tiny vials that can be worn as a necklace. Kaitlyn showed everyone her extracted DNA necklace from a year ago, thus demonstrating the resilience of DNA!

At this point, the presentation transitioned to Kjerstie Bourne who described how an infection with Valley Fever as a child, prompted her father, a professor of sociology, to partner with MDs and Phds to initiate a study to learn more about the disease and this experience ignited her love of science. Her love of science and interest in biotechnology stems from a desire to help others. She also emphasized that science has been an amazingly interesting, engaging, and also flexible career for her. She was able to change what she was doing based on her family and children's needs.

As Kjerstie currently works at a CRO that provides DNA sequencing and purification services, she explained that a CRO provides services for other research organizations, including both biotech and pharmaceutical companies as well as academic researchers. She explained that DNA is being used to trace people’s family history, for genetic testing, and medical diagnostics, as well as forensics, anthropology, paleontology, and archeology. Kjerstie provided insight on the molecular structure of DNA, but then also what DNA looks like when the scientists at Elim Bio receive it from researchers. Researchers often add circular DNA constructs called plasmids to bacteria to propagate and produce lots more of a particular DNA sequence; so Elim often gets DNA in bacteria either grown on agar plates, pelleted to the bottom of small Eppendorf tubes, or grown in culture in 96 well plates. Bacteria can also be provided in glycerol which can be frozen and woken up to grow later. Finally, DNA can also be extracted like the Biopolis young women showed us and dried in a tube. For their clients, Elim might then either purify the desired DNA from the bacteria in a quick format called a mini-prep or they might perform additional purification processes to ensure the DNA is free of bacteria known as endotoxins so that the DNA can be used in vivo without promoting an immune response to the bacteria. Elim also provides DNA sequencing and polymerase chain reaction (PCR) services. Since the next YWIB-Southern California summer series event, is going to focus on DNA sequencing technology, Kjerstie rather showed a wonderful video to demonstrate the way in which PCR allows one to amplify a specific sequence of DNA to create a ton of copies.

The event ended with Biopolis, Kjerstie, and Kristina fielding questions about DNA extraction. It was noticed, for example, that the color of the dish soap influences the color of the extracted DNA, so students were encouraged to try different things to optimize their own DNA extractions!

Tags:  2020  Southern California 

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WIB-Pittsburgh: Young Women In Bio Virtual Webinar for High School Students on Establishing Your Personal Brand, May 27, 2020

Posted By Joie Marhefka, Friday, June 26, 2020

On May 27, 2020, YWIB-Pittsburgh held its first virtual webinar event during the COVID-19 pandemic. Dr. Crystal Morrison from EverRise, LLC, shared with students her journey in her career starting from Arkansas and how she ended up in Pittsburgh. She discussed and shared with students what is “branding” and why in the Professional World it is important to develop your own brand and develop what you stand for. Dr. Morrison also shared the goals of networking and establishing a professional networking account using LinkedIn.

While high school students may not yet have an extensive resume, it is still important to begin with what you have. Students from at least four states attended including New York, New Jersey, Arkansas, and both on the Eastern and Western side of Pennsylvania. Students were able to ask questions in the zoom chat and share their thoughts to poll questions that Dr. Morrison asked during her talk.

Tags:  2020  Pittsburgh 

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WIB-Atlanta: Young Women In Bio - GEMS STEM Day at Agnes Scott, February 28, 2020

Posted By Claire Jarvis, Tuesday, June 2, 2020

On Friday, February 28, 2020, students from Alcovy High School came to Agnes Scott College and spent the day attending classes, touring the campus, and participating in different STEM activities with ASC faculty and students. The 20 high school students in attendance were members of the “Gifted Girls” group at Alcovy. The Agnes Scott students who organized the day are representatives of the Generating Excellence in Math and Science (GEMS) living and learning community. This annual event was established by an Agnes Scott College alum to give students from her alma mater the chance to experience STEM resources not available to them otherwise.

Click here for more photos 

In the YWIB sponsored activity, students learned about green chemistry and alternative fuels. Biodiesel is a cleaner burning renewable alternative to diesel fuel that is made from biological sources; namely vegetable oil or animal fats. Biodiesel is made through a transesterification reaction, a chemical process through which one ester is changed into another. In this lab, students made biodiesel using vegetable oil and practiced key chemistry laboratory techniques.

Students from both Alcovy and Agnes Scott showed significant interest in learning about the WIB organization and the GEMS were thrilled to have a national organization backing their event as a co-sponsor.


Tags:  2020  Atlanta 

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